Articles by Dr. Beppino Giovanella, as of 5/2/2001

139. V. Knight, N. Koshkina, J. C. Waldrep, B.C. Giovanella, and B.E. Gilbert. Anticancer effect of 9-nitrocamptothecin liposome aerosol on human cancer xenografts in nude mice. Cancer Chemother. Pharmacol. 44:177-186, 1999 .

138. C.F. Verschraegen, E. Gupta, E. Loyer, J.J. Kavanagh, A.P. Kudelka, R.S. Freedman, C.L. Edwards, Harris, N., M. Steger, V. Steltz, B.C. Giovanella, and J.S. Stehlin. A phase II clinical and pharmacological study of oral 9-nitrocamptothecin in patients with refractory epithelial, ovarian, tubal or peritoneal cancer. Anticancer Drugs 10:375-383, 1999.

137. J.S. Stehlin, B.C. Giovanella, et al. A phase II study of RFS(2000)-9-nitrocamptothecin in patients with advanced Pancreatic Cancer: A Preliminary Report. Int. J. Oncol. 14:821-831, 1999.

136. C.F. Verschraegen, E.S. Natelson, B.C. Giovanella, J.J. Kavanagh, A.P. Kudelka, R.S. Freedman, C.L. Edwards, K. Ende, and J.S.Stehlin. A phase I clinical and pharmacological study of oral 9-nitrocamptothecin, a novel water-insoluble topoisomerase I inhibitor. Anticancer Drugs 9;36-44, 1998.

135. Zhisong Cao, Nick Harris, Anthony Kozielski, Dana Vardeman, and Beppino Giovanella. Alkyl esters of camptothecin and 9-nitrocamptothecin: synthesis, in vitro pharmacokinetics, toxicity, and antitumor activity. J. Med. Chem. 41:31-37, 1998.

134. P. Pantazis, A. DeJesus, J. Early, and B. Giovanella. Altered sensitivities to anticancer and differentiation agents in etoposide-resistant human myeloid leukemia U-937 cells. J. Hematotherapy 7:81-92, 1998.

133. Jing Li, Clifford Yen, Danny Liaw, Katrina Podsypanina, Shikha Bose, Steven I. Wang, Janusz Puc, Christa Miliaresis, Linda Rodgers, Richard McCombie, Sandra H. Bigner, Beppino C. Giovanella, Michael Ittmann, Ben Tycko, Hanina Hibshoosh, Michael H. Wigler, and Ramon Parsons. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 274: 1943-1947, 1997.

132. P. Pantazis, D. Chatterjee, J. Wyche, A. de Jesus, J. Early, S. Plaschke and B. Giovanella. Establishment of human prostate tumor xenografts in nude and response to 9-nitrocamptothecin in vivo and in vitro does not correlate with expression of various apoptosis-regulating proteins. J. Exptl. Thera. & Oncology.

131. P. Pantazis, D. Chatterjee, Z. Han, J. Wyche, A. DeJesus, and B. Giovanella. Monocytic differentiation and synthesis of proteins associated with apoptosis in human leukemia U-937 cells acquiring resistance to vincristine. Eur. J. Haematol. 57:79-86, 1996.

130. Ahmed E. Ahmed, Sam Jacob, Beppino C. Giovanella, Anthony J. Kozielski, J.S. Stehlin, Jr,. and Joachim G. Liehr. Influence of route of administration on [3H]-camptothecin distribution and tumor uptake in CASE-bearing nude mice: whole-body autoradiographic studies. Cancer Chemother. Pharmacol. 39: 122-130, 1996.

129. H.R. Hinz, N.J. Harris, B.C. Giovanella, E.L. Ezell and J.G. Liehr. Stabilities of 3H- and 2-H-labelled camptothecins. J. Labelled Compounds & Radiopharm. Vol. 38;733-742; 1996.

128. M. Potmesil, Dana Vardeman, Anthony J. Kozielski, John Mendoza, John S. Stehlin and Beppino C. Giovanella. Growth Inhibition of Human Cancer Metastases by Camptothecins in Newly Developed Xenograft Models. Cancer Res. 55: 5637-5641, 1995.

127. P. Pantazis, A. De Jesus, J. Early, R. Rodriguez, D. Chatterjee, Z. Han, J. Wyche, and B. Giovanella. Development of human leukemia U-937 cell sublines resistant to doxorubicin: Induction of differentiation and altered sensitivities to topoisomerase-directed drugs. Anticancer Res. 15:1873-1882, 1995.

126. P. Pantazis, N. Harris, J. Mendoza, and B. Giovanella. The role of pH and serum albumin in the metabolic conversion of 9-nitrocamptothecin to 9-aminocamptothecin by human hematopoietic and other cells. Eur. J. Haematol. 55:211-213, 1995.

125. C.F.Verschraegen, J.T. Mendoza, A.J. Kozielski, and B.C.Giovanella. Modulation of the Response to Chemotherapy in a Human Melanoma Clone by the Site of Growth in the Nude Mouse. Anticancer Research 15:9-12, 1995.

124. S.S. Daoud, M.I. Fetouh, and B.C. Giovanella. Antitumor effect of liposome incorporated camptothecin in human malignant xenografts. Anti-Cancer Drugs 6:83-93; 1995.

123. H.R. Hinz, N.J. Harris, E.A.Natelson, and B.C. Giovanella. Pharmacokinetics of the In Vivo and In Vitro Conversion of 9-Nitro-20(S)-Camptothecin to 9-Amino-20(S)-Camptothecin in Humans, Dogs, and Mice. Cancer Res. 54:3096-3100, 1994.

122. P. Pantazis, J.T. Mendoza, A. DeJesus, J. Early, M. Shaw, and B.C. Giovanella. Development of Resistance to 9-Nitro-Camptothecin by Human Leukemic U-937 cells In Vitro Correlates with Altered Sensitivities to Several Anticancer Drugs. Anti-Cancer Drugs 5:473-479, 1994.

121. P. Pantazis, N. Harris, J. Mendoza, and B. Giovanella. Conversion of 9-Nitro-Camptothecin to 9-Amino-Camptothecin by Human Blood Cells In Vitro. Eur. J. Haematol. 53: 246-248, 1994.

120. P. Pantazis, J.T.Mendoza, A. DeJesus, E. Rubin, D. Kufe, and B.C.Giovanella. Partial Characterization of Human Leukemia U-937 Cell Sublines Resistant to 9-Nitro-Camptothecin. Eur. J. Haematol. 43:135-144, 1994.

119. P. Pantazis, D. Vardeman, J. Mendoza, J. Early, A. Kozielski, A. DeJesus, and B.Giovanella. Sensitivity of Camptothecin Resistant Human Leukemia Cells and Tumors to Anticancer Drugs with Diverse Mechanisms of Action. Leukemia Res. 19: 43-55, 1995.

118. P. Pantazis, A. Kozielski, R. Rodriguez, E. Petry, M. Wall and B.C. Giovanella. Therapeutic Efficacy of Camptothecin-Derivatives Against Human Malignant Melanoma xenografts. Melanoma Res. 4: 5-10, 1994.

117. E. Rubin, P. Pantazis, A. Bharti, D. Toppmeyer, B.C. Giovanella and D. Kufe. Identification of a Mutant Human Topoisomerase I with Intact Catalytic Activity and Resistance to 9-Nitrocamptothecin. J. Biol. Chem. 269: 2433-2439, 1994.

116. P. Pantazis, A.J. Kozielski, D.M. Vardeman, E.R. Petry and B.C. Giovanella. Efficacy of Camptothecin Congeners in the Treatment of Human Breast Carcinoma Xenografts. Oncology Res. 5: 273-281, 1994.

115. P. Pantazis, J.A. Early, J. T. Mendoza, A.R. de Jesus, and B.C. Giovanella. Cytotoxic Efficacy of 9-Nitrocamptothecin in the Treatment of Human Malignant Melanoma Cells In Vitro. Cancer Res. 54:771-776, 1994.

114. M. Harvey, A.T. Sands, R.S. Weiss, R.W. Wiseman, P. Pantazis, B.C. Giovanella, M.A. Tainsky, A. Bradley and L.A. Donehower: In Vitro Growth Characteristics of Embryo Fibroblasts Isolated from p53-Deficient Mice. Oncogene 8: 2457-2467, 1993.

113. P. Pantazis, J.A. Early, A.J. Kozielski, J.T. Mendoza, H.R. Hinz and B.C. Giovanella. Regression of Human Breast Carcinoma Tumors in Immunodeficient Mice Treated with 9-Nitro-Camptothecin: Differential Response of Nontumorigenic and Tumorigenic Human Breast Cells In Vitro. Cancer Res. 53: 1577-1582, 1993.

112. P. Pantazis, A.J. Kozielski, J.T. Mendoza, J.A. Early, H.R. Hinz and B.C. Giovanella. Camptothecin Derivatives Induce Regression of Human Ovarian Carcinomas Grown in Nude Mice and Distinguish Between Nontumorigenic and Tumorigenic Cells In Vitro. Intl. J. Cancer 55: 836-871, 1993.

111. P. Pantazis, J.T. Mendoza, A.J. Kozielski, E.A. Natelson and B.C. Giovanella. 9-Nitro-Camptothecin Delays Growth of U-937 Leukemia Tumors in Nude Mice and is Cytotoxic for Human Myelomonocytic Leukemia Lines In Vitro. Eur. J. Haematol. 50: 81-89, 1993.

110. P. Pantazis, H.R. Hinz, J.T. Mendoza, A.J. Kozielski, L.J. Williams, J.S. Stehlin and B.C. Giovanella. Complete Inhibition of Growth Followed by Death of Human Malignant Melanoma Cells In Vitro and Regression of Human Melanoma Xenografts in Immunodeficient Mice Induced by Camptothecins. Cancer Res. 52: 3980-3987, 1992.

109. D.R. Coil, B.C. Giovanella, P.J. Greeff, J.S. Stehlin and B.R. Davis. An Experimental Model for the Study of Thermochemotherapy In Vivo. Anticancer Res. 12: 1363-1372, 1992.

108. C. Verschraegen, B.C. Giovanella, J.T. Mendoza, A.J. Kozielski and J.S. Stehlin, Jr. Specific Organ Metastases of Human Melanoma Cells Injected into the Arterial Circulation of Nude Mice. Anticancer Research 11: 529-536, 1991.

107. S. Kharbanda, E. Rubin, H. Gunji, H. Hinz, B. Giovanella, P. Pantazis, and D. Kufe. Camptothecin and Its Derivatives Induce Expression of the c-jun Protooncogene in Human Myeloid Leukemia Cells. Cancer Res. 51:6636-6642, 1991.

106. B.C. Giovanella, H.R. Hinz, A.J. Kozielski, J.S. Stehlin, Jr., R. Silber and M. Potmesil. Complete Growth Inhibition of Human Cancer Xenografts in Nude Mice by Treatment with 20-(S)-Camptothecin. Cancer Res. 51: 3052-3055, 1991.

105. B.C. Giovanella, D.M. Vardeman, L.J. Williams, D.J. Taylor, P.D. de Ipolyi, P.J. Greeff, J.S. Stehlin, D.J. Slamon, R. Cailleau and H.E. Gary. Heterotransplantation of Human Breast Carcinomas in Nude Mice: Correlation Between Nude Takes, Poor Prognosis and Overexpression of the HER-2/neu Oncogene. Int. J. Cancer 47: 66-71, 1991.

104. F.Z. Bischoff, S.O. Yim, S. Pathak, G. Grant, M.J. Siciliano, B.C. Giovanella, L.C. Strong and M.A. Tainsky. Spontaneous Abnormalities in Normal Fibroblasts from Patients with Li-Fraumeni Cancer Syndrome: Aneuploidy and Immortalization. Cancer Res. 50: 7979-7984, 1990.

103. M.K. Dhaliwal, B.C. Giovanella and S. Pathak. Cytogenetic Characterization of Two Human Milk-Derived Cell Line (HBL-100) Passages Differing in Tumorigenicity. Anticancer Res. 10: 113-118, 1990.

102. B.C. Giovanella, J.S. Stehlin, M.E. Wall, M.C. Wani, A.C. Nicholas, L.F. Liu, R. Silber and M. Potmesil. DNA Topoisomerase I-Targeted Chemotherapy of Human Colon Cancer in Xenografts. Science 246: 1046-1048, 1989.

101. S. Heim, N. Mandah, K. Armeden, B.C. Giovanella, S.O. Yim, J.S. Stehlin and F. Mitelman. Multiple Karyotypic Abnormalities Including Structural Rearrangements of 11P in Cell Lines from Malignant Melanomas. Cancer Genet. Cytogenet. 35: 5-20, 1988.

100. M.A. Tainsky, D.B. Krizman, P.J. Chiao, S.O. Yim, and B.C. Giovanella. PA-1A Human Cell Model for Multistage Carcinogenesis: Oncogens and Other Factors. Anticancer Res. 8: 899-914, 1988.

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99. J.S. Stehlin, P.J. Greeff, P.D. de Ipolyi, B.C. Giovanella, G. Klein, C.J. McGaff, B.R. Davis, L.J. Williams, E.A. Natelson, and R.F. Anderson. Heat as an Adjuvant in the Treatment of Advanced Melanoma: An Immune Stimulant. Houston Med. J. 4: 53-61, 1988.

98. B.C. Giovanella. Human Melanomas: A Research Laboratory Perspective. Houston Med. J. 4: 53-60, 1988.

97. R.J.T. Corbett, R.L. Nunnally, B.C. Giovanella and P. Antich. Characterization of the 31p Nuclear Magnetic Resonance Spectrum from Human Melanoma Tumors Implanted in Nude Mice. Cancer Res. 47: 5065-5069, 1987.

96. C. Greco, R. Cavaliere, B. Giovanella, P.G. Natali and G. Zupi. Effect of Sequential Application of Hyperthermia and Chemotherapy on the Survival of a Thermoresistant Human Melanoma Culture. Cancer Biochem. Biophys. 9: 223-232, 1987.

95. M.A. Tainsky, F. Shamanski, D. Blair and B.C. Giovanella. Causal Role for an Activated N-ras Oncogene in the Induction of Tumorigenicity Acquired by a Human Cell Line. Cancer Res. 47: 3235-3238, 1987

94. T. Kozielski, A. Lockshin, B.C. Giovanella and J.S. Stehlin, Jr. A Method for Prolonged, Repeated Infusion of Nude Mice. Lab. Animal Sci., Dec. 1986: 696-698.

93. A. Lockshin, B.C. Giovanella and J.S. Stehlin, Jr. Quantitative Evaluation of Anticancer Agents Against Human Melanoma Cells Implanted in Nude Mice. Exp. Cell Biol. 54: 149-155, 1986.

92. A. Lockshin, J.T. Mendoza, B.C. Giovanella and J.S. Stehlin, Jr. 111Indium Labeling of Cultured Human Tumor Cells. Oncology 42: 322-327, 1985.

91. A. Lockshin, B.C. Giovanella, J.T. Mendoza, C. Warneke and J.S. Stehlin, Jr. Selective Cytotoxicity of 5-Hydroxyuridine for Human Colon Adenocarcinoma Cells. Cancer Treat. Repts. 69: 845-850, 1985.

90. J. Bergh, K. Nilsson, R. Ekman and B. Giovanella. Establishment and Characterization of Cell Lines from Human Small Cell and Large Cell Carcinomas of the Lung. Acta Path. Microbiol. Immunol. Scand. 93: 133-147, 1985

89. A. Lockshin, B.C. Giovanella, J.S. Stehlin, Jr., T. Kozielski, C. Quian and R.W. Apperson. Antitumor Activity and Minimal Toxicity of Concentrated Thymidine Infused in Nude Mice. Cancer Res. 45: 1797-1802, 1985.

88. A. Lockshin, B.C. Giovanella, D.M. Vardeman, J.T. Mendoza, C. Quian, T. Kozielski and J.S. Stehlin, Jr. Effectiveness of anticancer drugs determined in nude mice inoculated with [125]5-Iodo-2-Deoxyuridine Prelabeled Human Melanoma Cells. J.N.C.I. 74: 899-903, 1985.

87. A. Lockshin, B.C. Giovanella, P.D. de Ipolyi, L.J. Williams, Jr., J.T. Mendoza, S.O. Yim and J.S. Stehlin, Jr. Exceptional lethality for nude mice of cells derived from a primary human melanoma. Cancer Res. 45: 345-350, 1985.

86. B.C. Giovanella, J.S. Stehlin and D. Coil. Human tumors heterotransplanted in nude mice and rats: A comparative study. Exp. Cell Biol. 52:76-79, 1984.

85. J.S. Stehlin, B.C. Giovanella, A.E. Gutierrez, P.D. de Ipolyi and P.J. Greeff. 15 years experience with hyperthermic perfusion for treatment of soft tissue sarcoma and malignant melanoma of the extremities. Front. Rad. Ther. Onc. 18: 177-182, 1984.

84. A. Lockshin, B.C. Giovanella, T. Kozielski and J.S. Stehlin, Jr. Determination of cytotoxicity in vivo using 111Indium-labeled human tumor cells. Cancer Lett. 24: 179-185, 1984.

83. A. Lockshin, B.C. Giovanella, C. Quian, J.T. Mendoza, D.M. Vardeman and J.S. Stehlin, Jr. Correlation of cytotoxicity with elimination of Iodine125 for nude mice inoculated with prelabeled human melanoma cells. J. Natl. Cancer Inst. 73: 417-422, 1984.

82. A. Lockshin, J.T. Mendoza, B.C. Giovanella and J.S. Stehlin, Jr. Cytotoxic and biochemical effects of thymidine and 3-deazauridine on human tumor cells. Cancer Res. 44: 2534-2539, 1984.

81. M.A. Tainsky, C.S. Cooper, B.C. Giovanella and G.F. Vande Woude. An activated rasN gene: Detected in late but not early passage human PA 1 teratocarcinoma cells. Science 225: 643-645, 1984.

80. J. Bowen, R. Cailleau, B.C. Giovanella, S. Pathak and M. Siciliano. A retrovirus-producing transformed mouse cell line derived from a human breast adenocarcinoma transplanted in a nude mouse. In Vitro 19(8): 635-641, 1983.

79. F. Mitelman, E. Mark-Vendel, A. Mineur, B. Giovanella and G. Klein. A 3q+ marker chromosome in EBV-carrying nasopharyngeal carcinomas. Int. J. Cancer 32: 651-655, 1983.

78. R.D. Rossen, M.M. Crane, A.C. Morgan, E.H. Giannini, B.C. Giovanella, J.S. Stehlin, J.J. Twomey and E.M. Hersh. Circulating immune complexes and tumor cell cytoxins as prognosistic indicators in malignant melanoma: A prospective study of 53 patients. Cancer Res. 43: 422-429, 1983.

77. B.C. Giovanella, J.S. Stehlin, R.C. Shepard and L.J. Williams. Correlation between response to chemotherapy of human tumors in patients and the nude mice. Cancer 52: 14-20, 1983.

76. L.P. Rutzky, B.C. Giovanella, B.H. Tom, C.I. Kaye, P.D. Naguchi and B.D. Kahan. Characterization of a human colonic adenocarcinoma cell line, LS 123. In Vitro 19(2): 99-107, 1983.

75. I. Ernberg, G. Klein, B.C. Giovanella, J. Stehlin, K.J. McCormick, M. Andersson-Anvret, P. Aman and D. Killander. Relationship between the amounts of EBV-DNA and EBNA per cell clonability and tumorigenicity in two EBV-negative lymphoma lines and their EBV-converted subline. Int. J. Cancer 31: 163-169, 1983.

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74. J.M. Bowen, R. Cailleau, B.C. Giovanella, S. Pathak and M.J. Siciliano. Retrovirus-producing transformed mouse cell line derived from human breast adenocarcinoma transplanted in a nude mouse. In Vitro 19: 635-642, 1983.

73. A.C. Morgan, R.D. Rossen, K.J. McCormick, J.S. Stehlin and B.C. Giovanella. “Hidden” cytotoxic antibodies that react with allogeneic cultured fetal and tumor cells contained in soluble immune complexes from normal human sera. Cancer Res. 42:881-886, 1982.

72. G. Roos, A. Adams, B. Giovanella, E. Lundgren, K. Nilsson, I. Norderson and C. Sundstrom. Establishment and characterization of a human EBV-negative B cell line (MN 60). Leukemia Res. 6: 685-693, 1982.

71. B.C. Giovanella, R.C. Shepard, J.S. Stehlin, J.S. Venditti and B.J. Abbott. Effect of caloric restriction on the growth of human tumors heterotransplanted in Nude Mice. J.N.C.I. 68: 249-257, 1982.

70. R.S. Freedman, J.M. Bowen, A. Leivbovitz, S. Pathak, M.J. Siciliano, H.S. Gallager and B.C. Giovanella. Characterization of cell line (SW 756) derived from a human squamous carcinoma of the uterine cervix. In Vitro 18: 719-726, 1982.

69. K.J. McCormick, B.C. Giovanella, G. Klein, K. Nilsson and J.S. Stehlin. Diploid human lymphoblastoid and Burkitt lymphoma cell lines: Susceptibility to murine NK cells and heterotransplantation to nude mice. Int. J. Cancer 28: 455-458, 1981.

68. A.C. Morgan, Jr., D.R. Galloway, F.C. Jensen, B.C. Giovanella and R.A. Reisfeld. Immunochemical delineation of an oncofetal antigen on normal and Simian virus 40-transformed human fetal Melanocytes. Proc. Natl. Acad. Sci., USA 78(6): 3834-3838, 1981.

67. S.S. Lee, B.C. Giovanella and J.S. Stehlin. Activity of thymidine as a chemotherapeutic agents against human tumor xenografts in nude mice [Letter]. Cancer Res. 40:1764-1980.

66. M.C. Liau, C.F. Chang and B.C. Giovanella. Demonstration of an altered S-adenosylmethionine synthetase in human malignant tumors xenografted into athymic nude mice. J.N.C.I. 64: 1071-1075, 1980.

65. J. Bergh, K. Nilsson, L. Zech and B. Giovanella. Establishment and characterization of a continuous lung squamous cell carcinoma cell line (U-1752). Anticancer Res. 1:317-322, 1980.

64. M.A. Persuy, M. Ermonval, H.G. Suarez, Jean L. Daya-Gros, P. Nardeux, B.C. Giovanella, A.C. Kay and R. Cassingena. Cells transformed by transfer of isolated chromosomes from virus-transformed or "spontaneous" tumor cells. I. Biological properties of transplantability in nude mice. Exper. Cell Biol. 48: 51-65, 1980.

63. B.C. Giovanella. Effects of hyperthermia on cancers: An verview. St. Joseph Med. J. 15: 197-202, 1980.

62. B.C. Giovanella, J.S. Stehlin and S.O. Yim. Correlation of the thermosensitivity of cells to their malignant potential. Ann. New York Acad. Sci. 334: 206-214, 1980.

61. K.J. McCormick, B.C. Giovanella, D.C. Day, W.R. Parsons and J.S. Stehlin. An enzymatic assay for the detection of natural cytotoxicity. J. Imm. Method. 35: 83-90, 1980.

60. J.S. Stehlin, P.J. Greeff, B.C. Giovanella and L.J. Williams. Dramatic response of cancer to localized hyperthermia. New York State J. Med. 80: 70-72, 1980.

59. J. Zeuthen, J.O.R. Norgaard, P. Aner, M. Fellous, J. Wartiovaara, A. Vaneri, Z. Rosen and B.C. Giovanella. Characterization of a human ovarian teratocarcinoma cell line. Int. J. Cancer 25: 19-32, 1980.

58. L.J. Williams and B.C. Giovanella. Thymidine therapy: The first case report. The Med. J. of St. Joseph Hospital - Houston, 14: 69-76, 1979.

57. J.S. Stehlin, B.C. Giovanella, P.D. de Ipolyi and R.F. Anderson. Eleven years experience with hyperthermic perfusion for melanoma of the extremities. World J. Surg. 3: 305-309, 1979.

56. S.S. Lee, B.C. Giovanella, J.S. Stehlin, Jr. and J.C. Brunn. Regression of human tumors established in nude mice after continuous infusion of thymidine. Cancer Res. 39: 2928-2933, 1979.

55. D.S. Zaharko, B.J. Bolton, T. Kobayashi, R.G., Blasberg, S.S. Lee, B.C. Giovanella and J.S. Stehlin. Thymidine and thymine in biological fluids during high dose infusion of thymidine, mouse, monkey and man. Cancer Treatment Repts. 63: 945-950, 1979.

54. B.C. Giovanella, K. Nilsson, L. Zech, S.O. Yim, G. Klein and J.S. Stehlin. Growth of diploid, Epstein-Barr Virus carrying human lymphoblastoid cell lines heterotransplanted into nude mice under immunologically privileged conditions. Int. J. Cancer 24: 103-113, 1979.

53. J.S. Stehlin, Jr., B.C. Giovanella, P.D. de Ipolyi and R.F. Anderson. Results of eleven Years' experience with heated perfusion for melanoma of the extremities. Cancer Res. 39: 2255-2257, 1979.

52. B.C. Giovanella, J.S. Stehlin, R.C. Shepard and L.J. Williams. Hyperthermic treatment of human tumors heterotransplanted in nude mice. Cancer Res. 39: 2235-2241, 1979.

51. D.H. Crawford, B.C. Achong, N.M. Teich, S. Finerty, J.L. Thompson, M.A. Epstein and B.C. Giovanella. Identification of murine endogenous xenotropic retrovirus in cultured mini-cellular tumour spheroids from nude-mouse passaged nasopharyngeal carcinoma. Int. J. Cancer 23: 1-7, 1979.

50. P. Rivosecchi-Merletti, B. Giovanella, E. Bonmassar and A. Goldin. Growth and inhibition of mouse or human tumors in "nude" (athymic) mice monitored by the extent of 125I-5-Iodo-2_-deoxyuridine (125IUDR) uptake. Europ. J. Cancer 14: 1057-1064, 1978.

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49. B. Drewinko, L. Yang, B. Barlogie, M. Romsdahl, M. Meistrick, M.A. Malahy and B.C. Giovanella. Further biologic characteristics of a human carcinoembryonic ntigen-producing colon carcinoma cell line. J.N.C.I. 61: 75-83, 1978.

48. N. Kuzumaki, E.M. Fenyo, B.C. Giovanella and G. Klein. Increased immunogenicity of low antigenic rat tumors after superinfection with endogenous murine C-Type virus in nude mice. Int. J. Cancer 21: 62-66, 1978.

47. B.C. Giovanella, J.S. Stehlin, L.J. Williams, S.S. Lee and R.C. Shepard. Heterotransplantation of human cancers into nude mice. A model system for human cancer chemotherapy. Cancer 42: 2269-2281, 1978.

46. S. Finerty, J.E. Jarvis, M.A. Epstein, P.A. Trumper, G. Ball and B.C. Giovanella. Cytogenetics of malignant epithelial cells and lymphoblastoid cell lines from nasopharyngeal carcinoma. Br. J. Cancer 37: 231-239, 1978.

45. P.A. Trumper, M.A. Epstein, B.C. Giovanella and S. Finerty. Isolation of infectious EB Virus from the epithelial tumour cells of nasopharyngeal carcinoma. Int. J. Cancer 20: 655-662, 1977.

44. S.S. Lee, B.C. Giovanella and J.S. Stehlin, Jr. Effect of excess thymidine on the growth of human melanoma cells transplanted in thymus deficient nude mice. Cancer Letters 3: 209-214, 1977.

43. S.S. Lee, B.C. Giovanella and J.S. Stehlin, Jr. Selective lethal effect of thymidine on human and mouse tumor cells. J. Cell Physiol. 92: 401-405, 1977.

42. G. De The, M. Vuillaume, B.C. Giovanella and G. Klein. Epithelial characteristics of tumor cells in nasopharyngeal carcinoma passaged in nude mice: Ultrastructure. J.N.C.I. 57: 1101-1105, 1976.

41. B.C. Achong, P.A. Trumper and B.C. Giovanella. C-Type virus particles in human tumours transplanted into nude mice. Br. J. Cancer 34: 203-206, 1976.

40. K. Nilsson, B.C. Giovanella, J.S. Stehlin and G. Klein. Tumorigenicity of human hematopoietic cell lines in athymic nude mice. Int. J. Cancer 19: 337-344; 1976.

39. B.C. Giovanella, J.S. Stehlin and A.C. Morgan. Selective lethal effect of supranormal temperatures on human neoplastic cells. Cancer Res. 36: 3944-3950, 1976.

38. P.A. Trumper, M.A. Epstein and B.C. Giovanella. Activation in vitro by BUdR of a productive EB virus infection in the epithelial cells of nasopharyngeal carcinoma. Int. J. Cancer 17: 578-587, 1976.

37. B.C. Giovanella, J.S. Stehlin, C. Santamaria, S.O. Yim, A.C. Morgan, L.J. Williams, Jr., A. Leibovitz, P.J. Fialkow and D.M. Mumford. Human neoplastic and normal cells in tissue culture. I. Cell lines derived from malignant melanomas and normal melanocytes. J.N.C.I. 55: 1131-1142, 1976.

36. C. Kaschka-Dierich, A. Adams, L. Lindahl, G.W. Bornkamm, G. Bjursell, G. Klein, B.C. Giovanella and S. Singh. Intracellular forms of Epstein-Barr Virus DNA in human tumour cells in vivo. Nature 260: 302-306, 1976.

35. J.S. Stehlin, Jr., P.D. de Ipolyi, B.C. Giovanella, A.E. Guiterrez and R.F. Anderson. Soft tissue sarcomas of the extremity - Multidisciplinary therapy employing hyperthermic perfusion. Am. J. Surg. 130: 643-646, 1975.

34. G. Klein, B.C. Giovanella, A. Westman, J.S. Stehlin and D. Mumford. An EBV-genome negative cell line established from an American Burkitt lymphoma; receptor characteristics, EBV infectability and permanent conversion into EBV-Positive sublines by in vitro infection. intervirology 5: 319-334, 1975.

33. J.S. Stehlin, B.C. Giovanella, P.D. de Ipolyi, L.R. Muenz and R.F. Anderson. Results of hyperthermic perfusion for melanoma of the extremities. Surg. Gyn. Obst. 140: 338-348, 1975.

32. B.C. Giovanella, J.S. Stehlin and S.O. Yim. Establishment and characterization of a permanent cell line from a human teratocarcinoma. In Vitro 10: 382, 1974.

31. G. Klein, B.C. Giovanella, T. Lindahl, P.J. Fialkow, S. Singh and J.S. Stehlin. Direct evidence for the presence of Epstein-Barr Virus, DNA and nuclear antigen in malignant epithelial cells from patients with poorly differentiated carcinoma of the nasopharynx. Proc. Natl. Acad. Sci., U.S.A., 71: 4737-4741, 1974.

30. B.C. Giovanella, J.S. Stehlin and L.J. Williams. Heterotransplantation of human malignant tumors in "nude" mice. II. Malignant tumors induced by injection of cell cultures derived from human solid tumors. J.N.C.I. 52: 921-930, 1974.

29. B.C. Giovanella, A.C. Morgan, J.S. Stehlin and L.J. Williams. Selective lethal effect of supranormal temperatures on mouse sarcoma cells. Cancer Res. 33: 2568-2578, 1973.

28. B.C. Giovanella and J.S. Stehlin. Heterotransplantation of human malignant tumors in "nude" thymusless mice. I. Breeding and maintenance of "nude" mice. J.N.C.I. 51: 615-619, 1973.

27. B.C. Giovanella, S.O. Yim, A.C. Morgan, J.S. Stehlin and L.J. Williams. Brief communication: Metastases of human melanomas transplanted in “nude” mice. J. Natl. Cancer Inst. 50:1051-1053, 1973.

26. B. Giovanella and J.S. Stehlin. Metastases of human melanomas transplanted in "nude" mice. J.N.C.I. 50: 1051-1053, 1973.

25. B.C. Giovanella, S.O. Yim, J.S. Stehlin and L.J. Williams, Jr. Development of invasive tumors in the "nude" mouse after injection of cultured human melanoma cells. J.N.C.I. 48: 1531-1533, 1972.

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24. B.C. Giovanella, J. Liegel and C. Heidelberger. The refractoriness of the skin of hairless mice to chemical carcinogenesis. Cancer Res. 30: 2590-2597, 1970.

23. B.C. Giovanella, W.A. Lohman and C. Heidelberger. Effects of elevated temperatures and drugs on the viability of L1210 leukemia cells. Cancer Res. 30: 1623-1631, 1970.

22. R. Cavaliere, E.C. Ciocatto, B.C. Giovanella, C. Heidelberger, R.O. Johnson, M. Margottini, B. Monvodi, G. Moricca and A. Rossi-Fanelli. Selective heat sensitivity of cancer cells - biochemical and clinical studies. Cancer Res. 20: 1351-1381, 1967.

21. R. Cavaliere, B.C. Giovanella, M. Margottini, B. Mondovi, G. Moricca and A. Rossi-Fanelli. Selective heat sensitivity of neoplastic cells. Biochemical studies and therapeutic applications. Rend. Acc. Naz. Linc. 42: 164-172, 1967.

20. V.A. Triolo and B.C. Giovanella. Francesco Durante and the Connheim theory of oncogenesis. Physis. 8: 199-219, 1966.

19. B.C. Giovanella and C. Heidelberger. Mouse epidermal cells and carcinogenesis. I. Isolation of skin constituents. Cancer Res. 25: 161-183, 1965.

18. B.C. Giovanella, L.E. McKinney and C. Heidelberger. On the reported solubilization of carcinogenic hydrocarbons in aqueous solutions of DNA. Mol. Biol. 8: 20-27, 1964.

17. B.C. Giovanella, C.W. Abell and C. Heidelberger. The preparation and purification of tritiated carcinogenic hydrocarbons. Cancer Res. 22: 925-930, 1962.

16. B.C. Giovanella, C. Manni, P. Mazzoni and G. Moricca. Experimental studies on the fate of decamethonium. Can. Anaes. Soc. 8: 458-467, 1962.

15. A. Caputo, B.C. Giovanella and R. Giuliano. Anti-tumoral action of new sarcomycin derivatives. Nature 190: 819-821, 1961.

14. G. Moricca, B.C. Giovanella, C. Manni and R. Cavaliere. Estimation of decamethonium in biological fluids. Experientia 17: 216: 1961.

13. A. Caputo and B.C. Giovanella. The action of ionizing radiations on the respiration and on the aerobic and anaerobic glycolysis of Ehrlich mouse Aacites cells. Rad. Res. 13: 809-813, 1960.

12. D. Cavallini, B. Mondovi, B.C. Giovanella and C. De Marco. Radiochemical degradation of cystamine and derivatives. Ric. Scient. 30: 1178-1185, 1960.

11. B.C. Giovanella. Growth capacities of the Ehrlich ascites tumor inoculated into various organs of the mouse. Arch. It. Anat. Istol. Pat. 33: 393-412, 1959.

10. D. Cavallini, B. Mondovi, B.C. Giovanella and C. De Marco. Disulfide interchange by ionizing radiation. Science 131: 1441-1442, 1960.

9. D. Cavallini, B. Mondovi, B.C. Giovanella and C. De Marco. Degradation of thiotaurine by ionizing radiation. Nature 184: 61, 1959.

8. B.C. Giovanella. Morphological and histochemical alterations of Ehrlich ascites after repeated x-ray irradiations. Radiobiol. Lat. 2: 169-178, 1959.

7. B.C. Giovanella, C. Manni and G. Moricca. Turbidimetric detection of decamethonium. Experientia 15: 393, 1959.

6. C. Manni, G. Moricca, B.C. Giovanella and P. Mazzoni. Studies on the metabolism of some curares labeled with radioactive isotopes. Distribution of C14 labeled decamethonium in the rat. Simposio Internazionale su Curaro, Curarosimili e Curarizzanti, pp. 240-258, 1958.

5. A. Caputo and B.C. Giovanella. Experimental production of brain tumors in anura. Neoplas. 15: 232-245, 1957.

4. B.C. Giovanella and M. Pecini. Hematological changes in frogs injected with heterologous proteins. Med. Sper. 31: 429-449, 1957.

3. R. Cavaliere, B.C. Giovanella and G. Moricca. Influence of some anesthetic drugs on the liver studied by electrophoresis of bile proteins. Med. Sper., 31: 253-276, 1957.

2. A. Caputo and B.C. Giovanella. Experimental production of cerebral tumors in rats. Arch. It. Anat. 1st. Patol. 29: 467-497, 1955.

1. B.C. Giovanella and M. Pecini. Behaviour of some tissues of adult teleost transplanted in the anterior chamber of the eye of the frog. Rend. Acc. Naz. Linc., 16: 546-552, 1954.